well i figured that when you go higher, ingredient-wise, you can start getting the ingredient before it (i.e. if you just got an eye, you can get apples), so you should keep like one or two columns open for just getting the next ingredient. the space shouldnt be crowded with low ingredients so if you want an eye, keep only apples or dung in those 2 columns
i start from the right (cause they form to the left) and the higher ingredient will move left towards the center, where the highest pieces at the time are. the left hand side is usually for the lower ingredients (like dungs when i have crystals) and an open coulumn for when you want to put a low ingredient with a high ingredient into the middle column.
Keep going for combo chains, they make it much easier, so planning is involved. the fact that the next ingredient forms down then left is very important, the left and right columns are good for combo chains and the center is easiest to get gold with (the first piece at least) because the outside center columns are where the other stuff goes (when you have like a crystal and a potion - crystal goes to center, potion goes to right or left [outside center columns]) . the outermost columns are used to relieve the outside center (with combo chains).
once you get the first gold, the game is about survival (cause you can start gettin crystal chunks), so combo chains are necessary (for more room). planning and centralizing are basically the key strategies and it gets pretty easy to get the crystal right before gold.